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Gilbert's Syndrome | The Detoxification System | Understanding the Mutations | GS Symptoms | Things That Help & Things To Avoid Connections To: Allergies | Chronic Fatigue Syndrome | Candida | Soy | Hypothyroidism Also: Forums | Survey | Contact
Things That Help, Things To Avoid
Contents: Listings By Symptoms | Things That Help | Things That Arent Working | Things That Make It Worse
This is a work in progress and is being updated regularly. Check back regularly, as I will be steadily improving the site and adding more information.
Listings By Symptoms
(coming soon)
Headache
Things That Help
Gastroparesis (Digestive Problems)
Things That Help
http://www.medicinenet.com/script/main/art.asp?articlekey=8385&page=2
Treatments
Diet
Emptying from the stomach is faster when there is less food to empty, so smaller, more frequent portions of food are recommended. Soft foods (or preferably liquid) that do not require grinding also are emptied more easily. Moreover, in gastroparesis the emptying of liquids often is less severely affected than the emptying of solids. Fat causes the release of hormones that slow down the emptying of the stomach. Therefore, foods low in fat empty faster from the stomach. In patients with severe gastroparesis, sometimes only liquid meals are tolerated.
Controlling underlying conditions
High levels of glucose (sugar) in blood tends to slow gastric emptying. Therefore it is important to lower blood glucose levels in patients with diabetes to near normal levels with diets and medications. Individuals with a deficiency of thyroid hormone (hypothyroidism) should be treated with thyroid hormone. If bezoars are present, they should be removed (usually endoscopically).
Relieving nausea, vomiting, and abdominal pain
Drugs used to relieve nausea and vomiting in gastroparesis include promotility drugs (see discussion that follows) such as metoclopramide (Reglan) and domperidone, anti-nausea medications such as prochlorperazine (Compazine) and promethazine (Phenergan), serotonin antagonists such as ondansetron (Zofran), anticholinergic drugs such as a scopolamine patch (commonly used for treating motion sickness), drugs used for treating nausea in cancer chemotherapy patients such as aprepitant (Emend), and medical marijuana Marinol.
Drugs used to relieve abdominal pain in gastroparesis include non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin) and naproxen (Aleve), low dose tricyclic antidepressants such as amitriptyline (Elavil), drugs that block nerves that sense pain such as gabapentin (Neurontin), and narcotics such as tramadol (Ultram) and Fentanyl. Narcotic pain relievers as a group tend to cause constipation and slow emptying of the stomach, and, therefore, should be avoided or used with caution among patients with gastroparesis.
High levels of glucose (sugar) in blood tends to slow gastric emptying. Therefore it is important to lower blood glucose levels in patients with diabetes to near normal levels with diets and medications. Individuals with a deficiency of thyroid hormone (hypothyroidism) should be treated with thyroid hormone.
Oral Drugs. There are four oral drugs that are used to stimulate contractions of the stomach’s muscles, referred to as pro-motility drugs. These drugs are cisapride (Propulsid), domperidone, metoclopramide (Reglan), and erythromycin. Cisapride is an effective drug for treating gastroparesis; however, it was removed from the market because it can cause serious and life-threatening irregular heart rhythms. Despite this fact, it can be obtained for use through the pharmaceutical company that manufactures it (Janssen Pharmaceuticals) under a strictly monitored protocol but only for patients with severe gastroparesis unresponsive to all other measures. Domperidone has not been released for use in the US; however, it can be obtained if approval is obtained for its use from the US Food and Drug Administration. The fourth drug, erythromycin (E-Mycin, Ilosone, etc.), is a commonly-used antibiotic. At doses lower than those used to treat infections, erythromycin stimulates contractions of the muscles of the stomach and small intestine and is useful for treating gastroparesis.
It has been demonstrated recently that tegaserod (Zelnorm), an oral drug used for treating constipation in irritable bowel syndrome (IBS), increases emptying from the stomach just as it does from the colon. Further studies will be necessary to determine just how effective tegaserod is and how it compares to the other medications that are available for treating gastroparesis before its use can be recommended.
There are two important guidelines in prescribing oral drugs for gastroparesis. First, the drugs must be given at the right times, and second, the drugs must reach the small intestine so that it can be absorbed into the body. Since the goal of treatment is to stimulate muscular contractions during and immediately after a meal, drugs that stimulate contractions should be given before meals.
Most drugs must be emptied from the stomach so that they can be absorbed in the small intestine. The majority of patients with gastroparesis have delayed emptying of solid food, and pills and capsules, like solid food, do not empty well from the stomach. As mentioned previously, many patients with gastroparesis have less of a problem emptying liquids as compared with solid food. Therefore, liquid medications usually are more effective than pills or capsules.
http://www.infantrefluxdisease.com/gastroparesis.php
About Prokinetics
These drugs work to increase the speed at which stomach contents move through the digestive track. How they do this depends on the drug itself as listed below.
• Reglan® - U.S. /Maxeran® Canada (Metoclopramide)
This drug is a dopamine antagonist which is beneficial in the GI tract where dopamine inhibits motility. It stimulates and coordinates esophageal (esophagus), gastric (stomach), pyloric (valve between the stomach and small intestine), and duodenal (small intestine) peristalsis. Peristalsis refers to the smooth, rhythmic muscle contractions that cause food to pass through the digestive tract. It also works to increase lower esophageal sphincter (LES) tone and stimulates gastric contractions. Unfortunately, metoclopramide crosses the blood-brain barrier which can cause negative (and if not discontinued-possibly irreversible) side effects such as involuntary muscle spasms, motor restlessness, and inappropriate aggression. These side effects are more common in long term use (12 or more months).
• Motilium® - (Domperidone) - Currently not available in the U.S.
This is also a dopamine antagonist; however, domperidone does not cross the blood-brain barrier so it does not have the undesirable side effects that metoclopramide may. It works to increase esophageal peristalsis, LES pressure and gastric contractions.
• Erythromycin - An antibiotic with the side effect of increasing gastric motility. This is currently being widely used in low doses (not the higher antibiotic doses) for delayed gastric emptying as this does not have the unfortunate side effects that are possible with metoclopramide.
• Urecholine® (Bethanchol) - Urecholine is used to treat urinary and bladder problems. It helps to empty the bladder and often stimulates gastric motility, increases gastric tone, and restores rhythmic peristalsis improving gastric emptying time.
http://www.gitract.info/stomach-disorders/gastric-emptying.php
Routine treatment for gastroparesis involves a change in dietary habits to control blood sugar levels. A dietary regimen of up to six small meals a day instead of three large meals is generally recommended.
Other treatments for delayed gastric emptying include insulin to control blood glucose levels, medications such as Reglan® (metoclopramide)..
http://www.gi.org/patients/gihealth/gastroparesis.asp
Medications associated with impaired gastric emptying
Narcotic pain medications
Tricyclic antidepressants
Calcium channel blocking medications
Clonidine
Dopamine agonists
Lithium
Nicotine
Progesterone containing medicationsSome foods are more difficult than others for the stomach to digest. Fatty foods take a longer time to digest, as do foods that are fibrous, like raw vegetables.
Things That Help
Medications
Imitrex - Headaches
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=79.topic
Lisa
I also have headaches that last for days. I only treat the symptoms. My doctor prescribed Imitrex (which is for migraines) and is very effective. I find this to be a very strong drug, however, helps me get through the day at work
Domperidone / Motilium - Gastroparesis (Digestive Symptoms)
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=102.topic
DianaC
I also suffer from IBS, which isn't related apparently (but I notice a lot of suffers mention IBS). It is very confusing, you don't really know what is GS and what isn't when you aren't feeling well. I was prescribed domperidone which I have to say was just marvelous for about a year and then various things occurred which led to the discovery of extremely high prolactin levels. This is a side effect of domperidone so be careful, don't be fobbed off if you start to have menopausal type symptoms, get your prolactin checked. Flare-ups are cyclic in nature in my experience, especially if you have IBS as well as flare-ups of this are affected by hormone levels…
Zrxsheep
Hi a piece of advice for all those on Domperidone.
I have been on Domperidone for 11-12yrs and very recently i have found out after going to a head doc to deal with Anxiety that Domperidone was a tab they used back in the 80's in different institutions this is a bad tablet, apparently it should only be used for 12 weeks max, i have been on it for 11-12yrs and cannot get off it, if you look it up and do research on it it is a group of tablets that can caused tremors and shakes (simular to Parkinisom).I agree it works at first and the end result fades with time now i cannot function without it and the withdrawel symptons are an exagerated version of why you took it in the first place, this is a nasty drug try others first and use only if there are no other options available to yourself
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=24.topic
Enoch
My main symptom is nausea (no yellow eyes or abdominal pain). My Doctor prescribes Metoclopramide (Maxolon) and I also take Domperidone (Motillium) . They don't kill the nausea but they do help.
Remeron - Depression
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=102.topic
Paco Deth
(in regards to extreme nausea)
Then he had me try Remeron, ah the holy grail. Now this medicine made a big difference for me for quite a while. Basically the checkup before he prescribed Remeron he couldnt even touch me, if he tried to put that stethoscope near my neck or on my stomach I would gag and almost get sick. So after a few weeks of Remeron I came in with a smile on my face, felt fine, he could punch me in the gut and although unpleasant wouldnt really make me sick. Well Remeron worked 80-90% of the time. High stressful and anxiety instances I still felt kind of sickly but in general I felt pretty good… Now 4 years later it seems that I have become immune to Remeron.
http://www.drugs.com/remeron.html
What is Remeron?
• Remeron is in a class of drugs called antidepressants. Remeron affects chemicals in your brain that may become unbalanced and cause depression.
• Remeron is used to relieve symptoms of depression such as feelings of sadness, worthlessness, or guilt; loss of interest in daily activities; changes in appetite; tiredness; sleeping too much; insomnia; and thoughts of death or suicide.What should I discuss with my healthcare provider before taking Remeron?
• Before taking Remeron, tell your doctor if you have liver disease;
Metoclopramide / Reglan / Maxalon / Maxeron - Gastroparesis (Digestive Symptoms)
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=102.topic
DianaC
Maxalon is very good for the nausea if its really extreme, but I find sipping mineral water (sparkly or still) with some slices of lemon or lime, or in summer sprigs of fresh mint, can be very helpful.
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=24.topic
Enoch
My main symptom is nausea (no yellow eyes or abdominal pain). My Doctor prescribes Metoclopramide (Maxolon) and I also take Domperidone (Motillium) . They don't kill the nausea but they do help.
Dimenhydrinate / Gravol - Nausea, Vomiting, Dizziness
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=24.topic
18eeyore
my mom is a nurse and she told me about the " Anti - Nauseant pills (dimenhydrinate tablets usp) they help with Nausea, vomiting all though I don't get sick when I feel naseased they also help with dizziness.
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=24.topic
ashley
I have recently been diagnosed with GS at the age of 34. I started with the severe nausea about a year and a half ago, when my daughter was almost 1. It was so bad that i couldn't get out of bed until i took gravol. i have lost quite a bit of weight and am unable to gain it back.
Compazine - Nausea, Vomiting, Anxiety
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=24.topic
July15
I suffered from nausea so bad for 7 years that I had to take Compazine and other anti nauseant type medication.
Phenobarbital - Reduces Bilirubin
While phenobarbital does reduce bilirubin levels, there are numerous side effects and it is addictive. Since there are safer and less expensive ways to reduce bilirubin levels, phenobarbital would not be my first choice.
PERSONAL: Gilberts Web Forums
Katheryn23
Lots of people reported taking it (phenobarbitol) and my gastro said it is supposed to reduce jaundice.
Azvessey
I used to used the anti-convulsant phenobarbital up until recently but have now changed to a similar drug called Clonazepam which has somehow tripled the variety of foods which I can eat without regret. I still use a small additional dose of phenobarbital, 15mg, as well as the Clonazepam if I have enjoyed a particularly fatty meal. I combine the Clonazepam with a low carbo diet where and when possible.It has been reported that Phenobarbital taken at a rate of around 20 to 30 mgs a day will reduce bilirubin levels by about one third max. Strict compliance to really inconvenient but healthy and life prolonging diets will result in far more personal vitality and balance.
I just like to use the pharmaceuticals as occasional props so that I can get out occasionally and be like a normal healthy, gracefully aging person rather than the disabled pensioner that I have become. I have for 30 years encountered a complete lack of helpful advice offered to me by the majority of the medical advisors who have tried to convince me that GS (and it's accompanying illnesses) was just another variance of normal.
For me phenobarbital produced fairly quick results and provided that the 30 mg a day limit is not exceeded the duration of useful affect is not shortened. Most sufferers will benefit from a supplement of between 15 to 30 mgs a day from my experience.
Floraisles
Yes it does help, my son uses it from time to time. He usually takes 60mg at night and 30mg in the morning for 10 days only. This is enough to clear the symptoms for 6months to about 2 years. When he was younger he needed a course roughly every 6 months, but after 20 years he only requires it every 1-2 years.
Imgeha
If you do a google search on phenobarbital it comes up with some pretty alarming stuff, which suggested to me that this is not a drug to be messed around with or taken lightly. I personally would prefer to be under the guidance of a doctor ...
Mnol
My doctor tried me on Clonazepam 10 mg. and all I wanted to do was sleep, couldn't stay awake ? I usually have problems with most drugs, so this didn't surprise me. I still have my bad stomach and seems it will always be that way. Just have to watch what I eat.
Branwelt
yes it works. I took it (phenobarbitol) only for 5 days in a small dose.
But sometimes I had weird head feelings.
My UCB before Pheno was 4,7mg/dl and after 5days taking pheno I had 2,8mg/dl UCB . And now after one week without phenobarbital my UCB decreased to 2,2 mg/dl. 2,2 is not worse. Under 2,5 the symptoms of Gilbert syndrome do not exist. but the question is how long can this level be hold?? Phenobarbital has a half-life period of (96h!!!!!) . this means that after one week without pheno, i have still small amounts of pheno in my blood.
Phenobarbital and other enzyme inducers of the bilirubin-UDPGT system will normalize plasma bilirubin in patients with Gilbert syndrome.
http://www.ercp.ucla.edu/pages/info/symptoms/unconjugated-hyperbilirubinemia.html
Phenobarbital works by inducing the activity of bilirubin UGT-1. (this is used in treatment of those with Crigler-Najjar Symdrome)
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=139.topic
yates66
I take 120mg of Phenobarbitol 60 at night and 60 in the morning. It has brought my bili down quite a bit but my eyes are still yellow, mainly in the afternoons... I have been taking Pheno for about two years for my Gilberts. It wasnt easy getting my doctor to prescribe it.I told him I was sick and tired of people asking me if I had hepititus and I brought in case studies were they treated people with our condition with pheno.If you go to google and type in phenobarbitol and gilberts you will find plenty of amo to take to your doctor. The only side effects I have are delayed ejaculation because pheno is a anti convulsant.When I first started taking it I got a little sleepy after I took a dose but that soon went away.Its a very cheep drug and it does help with the jaundice.Doug
As far as pheno, that is a really tough drug on your sytem. Best to go another route if possible. Also if you live in the US, you may get in some major trouble importing it.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=23.topic
SumariMike
I have heard that the effects are far outweighed by the side effects which are much more unpleasant than Jaundice and lethargy.azvessey
I prefer to use diet to control my GS health but I still pop a 30mg tablet of phenobarbital occasionally when I've eaten (or drunken) something that didn't agree with my liver. I honestly think that phenobarbital is a wonder drug for people with GS but in my opinion there is no substitute for a healthy, low sugar, low carb, high protein diet... At 20mg a day I didn't didn't notice any undesirable side effects1) How long have you been taking phenobarbitol?
About 18 months.
2) Are you still taking it? If so, what dosage? 20 mg?
One 30mg tablet one day, half a 30mg tablet the second day, this results in an average of 22mg by the time I lose a few crumbs in the cutting.
3) Did that dosage help in lowering your bilirubin?
Research indicates that doing this will lower your bili by around 30% i.e. I was 30-40µmol/ml/day so pheno dropped me to around 22µmol.
4) If you are not taking phenobarbitol now, did your bilirubin stay low or rose after you stopped?
No, I stopped pheno when my I sorted my diets and found a way to combine them correctly. My bili will return to its usual upper limits immediately upon stopping the pheno or abandoning the diets.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=42.topic
Floraisles
My son was diagnosed with GS adout 22 years ago -- he had all the symptoms described by on these pages i.e. abdominal pain, fatigue, nausea, irritability. After long discussion with our GP at the time it was decided to treat him with Phenobarbitone tablets 30mg -- 2tablets at night and 1 tablet in the morning for 10 days only. It worked like magic! At first he required a repeat course roughly every 6 months or so but now after 20 years he only requires a course every 1-2 years.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=152.topic
ddterrell
I just turned 20 in June an the doctor told me that i have gilberts syndrome about 6 months ago. He prescribed me some phenobarbitial but that did not help at all.
http://www.drugs.com/mtm/phenobarbital.html
What is phenobarbital?
• Phenobarbital is in a class of drugs called barbiturates (bar bi TURE ates). Phenobarbital depresses the activity of your brain and nervous system.
• Phenobarbital is used to induce sleep, to treat insomnia (for up to 2 weeks), to prevent seizures, and to treat seizures that are already occurring.Who should not take phenobarbital?
• Do not take phenobarbital if you have
· porphyria,
· liver disease
• Phenobarbital is in the FDA pregnancy category D. This means that it is known to harm an unborn baby. Do not take phenobarbital if you are pregnant. However, if you take phenobarbital to control seizures, do not abruptly stop taking this medication, because a seizure could occur and this could be more harmful to an unborn baby. Talk to your doctor about treatment during pregnancy.What are the possible side effects of phenobarbital?
• If you experience any of the following serious side effects, stop taking phenobarbital and seek emergency medical attention or call your doctor immediately:
· an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
· a fever or a sore throat;
· sores in your mouth;
· broken blood vessels under your skin; or
· easy bruising or bleeding.
• Other, less serious side effects may be more likely to occur. Continue to take phenobarbital and talk to your doctor if you experience
· drowsiness or dizziness;
· confusion;
· agitation, irritability, or excitability;
· nightmares, nervousness, or anxiety;
· headache; or
· "hangover" effect (drowsiness the day after a dose).
• Phenobarbital is habit forming, which means that you can become addicted to it. Your doctor will want to monitor how much medicine you are taking. Your dosage may have to be reduced slowly to prevent withdrawal effects.
Clofibrate / Abitrate / Atromid-S - Reduces bilirubin, cholesterol
This is a cholesterol-lowering drug that also lowers unconjugated bilirubin by 65%.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6697662&dopt=Abstract
Effect of clofibrate on the metabolism of bilirubin, bromosulphophthalein and indocyanine green and on the biliary lipid composition in Gilbert's syndrome.
Clofibrate (20 mg day-1 kg-1 body weight) given orally for 2 weeks to 18 subjects with Gilbert's syndrome reduced the total serum bilirubin concentration from 44.4 (22.1-71.7) mumol/l (median, range) to 15.0 (7.9-28.9) mumol/l, mainly by decreasing the 'indirect' fraction to 34.5% of pretreatment values. In contrast to treatment with phenobarbitone, clofibrate did not change the ratio of bilirubin mono- to di-conjugates in bile... As expected, the cholesterol saturation of bile increased in all subjects. These results suggest that clofibrate increases mainly the glucuronidation of bilirubin, promoting as such the overall hepatic transport in Gilbert's syndrome.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=179.topic
yates66
Has anybody tried clofirate? I read a couple of articles that say it lowers bili. I know in the interduction page they say its bad for Gilberts so Im a little confused.
www.emedicine.com/med/topic1066.htm
www.clinsci.org/cs/066/cs0660389.htmdjk217
Yes, I have - it works on jaundice pretty well. I'd say I'm 90% cleared up. I don't think it is bad for people with Gilbert's - my Dr. has assured me at least. 600 Mg, twice daily.dmy222
some sites don't recommend this drug citing the fact that it's poorly metabolised.However there are medical websites stating how beneficial this drug is for gilberts syndrome
http://www.bioscreenmedical.com/index.html?members/gilberts.html
www.emedicine.com/med/topic1066.htm
http://www.ijppediatricsindia.org/article.asp?issn=0019-5456;year=2005;volume=72;issue=2;spage=123;epage=126;aulast=MohammadzadehIt maybe time to revisit the doctor now that there's a drug with seemingly less side effects than phenobarbitol that appears to clear jaundice.
http://www.nlm.nih.gov/medlineplus/druginfo/uspdi/202150.html
You may have read or heard about a study called the World Health Organization (WHO) Study. This study compared the effects in patients who used clofibrate with effects in those who used a placebo (sugar pill). The results of this study suggested that clofibrate might increase the patient's risk of cancer, liver disease, and pancreatitis (inflammation of the pancreas), although it might also decrease the risk of heart attack. It may also increase the risk of gallstones and problems from gallbladder surgery. Other studies have not found all of these effects.
The presence of other medical problems may affect the use of clofibrate. Make sure you tell your doctor if you have any other medical problems, especially:
• Gallstones or
• Stomach or intestinal ulcer—May make these conditions worse
• Heart disease or
• Kidney disease or
• Liver disease—Higher blood levels may result and increase the risk of side effects
• Underactive thyroid—Clofibrate may cause or make muscle disease worse
Gemfibrozil - Reduces Bilirubin, Cholesterol
This is another cholesterol-lowering drug that also lowers bilirubin.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=184.topic
djk217
Gemfibrozil - it's a cholesterol lowering drug, but if you ask your Dr. for it, he may already know, or will know that it lowers bilirubin. The thing is, you're pretty young, so they may try to resist you taking it, but I believe if you try it, it will clear up your eyes by about 90%. I had to sign a special consent form that stated I was using it for a different purpose than what it is intended for - since I don't have high cholesterol and I would bet at your age, you would not either. BTW - I take two 600 Mg pills a day. You're supposed to take it about 1/2 hour before eating for it to be most effective.
Dextromethorphan - Depression, Brain Fog, Headache, Fatigue
This worked really well much of the time to counter the effects of my allergy-induced emotional, behavioral, and social symptoms. For more information about it and to find out why exactly it worked, look at the Dextromethorphan section under Allergies.
Clonazepam / Klonopin - Panic Attacks
It is a highly potent anticonvulsant, amnestic and anxiolytic.
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=123.topic
azvessey
I have used this drug (clonazepam) at up to 8mg per day at which point I start to lose my 'edge'. 2mg per day is about the smallest dose I can take and still gain some relief. I don't actually suffer from depression as such and I only use a low dose antidepressant to help with sleep. In my opinion clonazepam is a very helpful drug for controlling a number of anxiety/depressive-like conditions.
Amitriptyline / Elavil / Tryptanol / Endep / Elatrol / Tryptizol - Depression
This is a tricyclic antidepressant.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=49.topic
ALS02
I was prescribed Amitriptyline for my current tingling sensations and that also helped the 'blues'. Everything now seems under control and I am much happier.
Lexapro - Depression
This is a SSRI antidepressant.
PERSONAL: Gilberts Web Forums
jaundicedjim
Recently, I had my colon checked out by colonoscopy (don't worry, it wasn't too bad since I was knocked out for it--just the awful stuff they make you drink to clear you system out--yuck!). The doctor confirmed it was irritable bowel syndrome, and that the panic attacks were triggering it and vice versa. Since then, I've been taking fiber supplements (4g per day, just a little), and I'm on Lexapro 10mg. This has helped sooooo much!!!
Penicillin - Reduces Bilirubin
Several people have had bad reactions to penicillin, and for many people antibiotics triggered the first onset of Gilbert's Syndrome symptoms. My experience with Rocephrin and Omnicef was that it caused a significant increase in my intolerance to carbs, possibly from candida getting into my blood. I would not recommend this as a good way to reduce bilirubin. Not by a long ways.
http://www.gilbertssyndrome.org.uk/Gilbert's%20Syndrome%20All%20About%20Bilirubin.html
Drugs that decrease bilirubin measurements include barbiturates, caffeine, penicillin and high dose salicylates.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=196.topic
theredbulljunky
Penicillin!!!Yep thats it!but why you ask,well im glad you asked my fellow sufferers.When i was in hospital a few years back,with a bad leg wound,i was put on a drip and given penicillin,now i wasnt even thinking about my eyes at the time,but when i came out.."WOW"!!My eyes were whiter then they have ever been in my life,i coudnt believe it,now for ages after i just put it down to being on a drip,having water going into me all the time,but no matter how much water i drink,it only ever helps me marginely.So i always said to myself i will try penicillin one day for a period,and that time is now.I Have tried virtually everything out there and be surprised to meet someone who has tried more things,none of which have really helped… i did look up penicillin and to suport my suspicions it turns out it is supposed to reduce billi levels
Hydrocortisone / Cortisol - Reduces Swelling, Immune Response
Hydrocortisone is a steroid. I would be wary of this one. First, this may be a problem unrelated to Gilbert's Syndrome. Second, there is evidence that cortisone aids the growth of candida, which may be related to Gilbert's Syndrome. If so, this would do more harm than good. More evidence is needed, and this shouldnt be used unless a blood test reveals low cortisol.
http://p075.ezboard.com/fgilbertswebfrm4.showMessage?topicID=64.topic
Lisa1702
But one thing that did show up in my blood tests results was that my level of cortisol in my body was too low. This is the hormone/steroid which regulates blood sugar and energy levels. I was put on a course of hydrocortisone (cortisol tablets) for 6 weeks – this made a huge difference, my symptoms reduced by 75%.
I have now come off the tablets (long term side effects are not good, so it’s best to come off them as soon as possible) am back at work part time and have adjusted my lifestyle to try and minimalism the effects of ME. Because I am naturally low on cortisol I do still have problems with low blood sugar; so I have cut out chocolate and things high in sugar, reduced the amount of stimulants I have (tea, coffee, etc), cut down on alcohol (alcohol does make me much worse, but I’m 24 and have to have some fun!), and eat a high carb diet – I have to eat every 2-3 hours or I start to get faint, cold, shaky etc through low blood sugar.
Supplements
Royal Jelly - Fatigue
http://p075.ezboard.com/fgilbertswebfrm4.showMessage?topicID=56.topic
DaveH439
Liquid Royal Jelly seemed to do me good but the brand I used was taken off the market when there was a scare with Chinese honey production. I feel that the B vitamins in the liquid Royal Jelly played an important part in the product. I didn't get the same reaction with vitamin B tablets though.
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=60.topic
DaveH439
I found relief from the fatigue by using liquid Royal Jelly. Best results for me are after at least one to two weeks and I take it for a month at a time then have a break for a while. The product I use is Ortis brand and is called Api Regis Liquid Royal Jelly. Have a look on my name for other posts and the details of the product are listed on one of them. The backache and joint pains seemed to improve when I took Zinc and Selenium capsules.
Livatone Plus - Reduces Bilirubin, Fatigue, Liver Pain, Digestive Problems
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=201.topic
kdhsgf
I have spoken to some ppl that have found benefits in taking Livatone Plus, which has apparently subsided their yellowness quite considerably
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=161.topic
cstarr
Has anyone tried Livatone? I bought some from the internet two weeks ago and have been taking it for just under a week now (the order took ages to come through) I've noticed a dramatic change in how I'm feeling now. I was diagnosed as having GS last November and am currently waiting to see a stomach specialist (stomach problems since January this year) My doctor doesn't believe that the two are linked but my symptons since taking livatone have almost disappeared. I won't go on about the stomach problem as i don't know what the problem is yet but liver wise i've noticed that the toxic feeling has nearly vanished, i have more energy, jaundice symptoms gone. I used to find that i would have a build up whereby i would feel very yuk for a week and then would get jaundice, lack of appetite, liver pain, no energy - almost flu like symptons. Diet didn't really help - i've been keeping a food diary for the last month and a half (due to stomach problem) There are no major diet changes that point to an attack of gs although i am much healthier now than back in November when first diagnosed which is good.Everyone's symptons vary depending on the individual but i have found that livatone has really helped me feel tonnes better. The only side effect that i have noticed after taking them for a week is green wee (usually in the morning but this returns to normal later in the day) It also makes me feel full up quite quickly so i have noticed a bit of a weight loss (apparently there is something in livatone which aids weight loss - taurine) i have to make sure that i'm eating enough at the right times of the day.
I'm on livatone plus... I've seen a def improvement and have just started swimming again - i didn't have the energy before.
(later) I've recently got back from holiday (lots of trekking in Venezuela) I had about 6 days when I couldn't sleep so had an attack of jaundice and liver pain but I know that it would have been much worse without the tablets.
kdhsgf
here is a link on it: http://www.thexton.com.au/product/Livatone__Plus__-__240__CapsulesWell just finished my first week on it... and I do feel better... on the first day I did notice nausea, but later dissipated... It seems to work quite well... although I get those headaches when I haven't gotten good sleep...
(later) I have been taking the powder twice a day before a meal... and I have not felt sick in ages... I feel really good... I don't get the flu like symptoms as much and my sleep is hardly broken... I stand by this product, it's truly worth having a go...
imgeha
Been taking mine for two days now, and am hopeful. The headache went the first day, but came back with a vengeance the next day, along with nausea - detox I presume. Today I feel better again.darianne99
Can I just say I am amazed!! I have been taking these pills and for the first time in years the whites of my eyes are white!! And to top it off I have the flu as well. Which would make me even have yellower eyes than normal. Not sure about the more energy as I am flued up and have three children but will keep everyone posted. Still feel nauseous as well.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=83.topic
dmy222
One of the main ingredients is milk thisle, only tried for about a week (imported) and got the same side effects as milk thistle, heavyness tiredness e.t.c.
Me:
I'm glad this is working for some people. I just looked at the ingredient list for the Livatone Plus, and it's got Nicotinamide, otherwise known as Niacin or Vitamin B3, which is known to raise bilirubin levels.
It's possible the rest of the good stuff in there more than makes up for it. Just for reference, here's the contents of Livatone PLUS:
Glutamine
Glycine
Taurine
Cysteine
Vitamin C
Vitamin E
Natural Carotenoids
Thiamine (Vitamin B1)
Riboflavine (Vitamin B2)
Nicotinamide (Vitamin B3)
Calcium Pantothenate (Vitamin B5)
Pyridoxine (Vitamin B6)
Cyanocobalamin (Vitamin B12)
Folic Acid
Biotin
Inositol
Lecithin
Zinc
St Mary’s Thistle (Milk Thistle)
Cruciferous Vegetables
Green TeaAnd here are the contents of Livatone (the original):
Psyllium
Taurine
Dandelion
Globe artichoke
St Mary’s Thistle
Slippery Elm Bark
Artichoke Extract & Sarsaparilla Root - Reduces Bilirubin, Fatigue, Inflammation, Loss of Appetite, Weakness
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=97.topic
hayesmoore
I thought Imight tell you about 2 new herbs which I am trying out myself. These herbs are extracts of Artichoke (a tasty delicacy) and Sarsaparilla root. Apparently both of these herbs have been used for a long time to treat patients of liver disease. They somehow regenerate and protect the liver and help the flow of bilirubin.You can find this page at www.extremehealthusa.com/press6.htm
The following are the most imprtant points:
-The herbs were taken for between 30 to 90 days.
-There was between 25% and 39% reduction in bilirubin.
-There was an increase of between 9% and 37% increase in serum albumin levels.I dont know what dosage was used, so I suggest just using whatever the reccommneded dose is. I am using 425mg of Sarsaparilla (1 capsule in morning) and 600 mg of Artichoke (1x300mg in morning 1x300mg at night).
(me: later) I have been using the Artichoke and Sarsaparilla for just 3 days now and already I am seeing very good results. I now have no yellowing of the eyes at all and I am feeling great!!!
Here is the dosages:
1 x 425 mg of Sarsaparilla (capsule) in the morning
1 x 300 mg of Artichoke (tablet) in the morning
1 x 300 mg of Artichoke (tablet) at nightThe Sarsaparilla I bought in Holland and Barrett and because Artichoke is quite expensive there, I bought that online at www.zipvit.co.uk. Their prices are v good and they deliver internationally. They do not seel Sarsaparilla though.
The Artichoke and Sarsaparilla combination for me seems to work far quicker than St Johns Wort did, which took at least 3 to 4 weeks to see any improvement.
http://www.extremehealthusa.com/press6.htm
PHYSIOLOGY
· Extracts of artichoke leaf have been found to stimulate bile production in the liver and bile release from the gall bladder and thus found effective in helping to eliminate toxic substances normalizing blood cholesterol levels lowering blood lipids and providing liver protective qualities.
· The root of the sarsaparilla plant is considered by European physicians to be an alterative tonic blood purifier diuretic (increases urine output) and diaphoretic (increases perspiration).INTERPRETATION OF RESULTS OBTAINED IN A DOUBLE BLIND TEST MADE IN THE GENERAL HOSPITAL MEXICO WITH THE PRODUCT LIVER SUPPORT ON PATIENTS HAVING CHRONIC ALCOHOLIC HEPATIC DISEASE.
ASCITES- Effusion and accumulation of serous fluid in the abdominal cavity. experimental group (Liver Support) experienced a 28.8% reduction of ascites while the placebo group experienced no change The.
ENCEPHALOPATHY- a DEGENERATIVE DISEASE OF THE BRAIN. Hepatic encephalopathy- a condition usually occurring secondarily to advanced disease of the liver. It is marked by disturbances of consciousness that may progress to deep coma (hepatic coma) psychiatric changes of varying degree flapping tremor and fetor hepaticas. Also called portal-systemic encephalopathy. Patients on Liver Support experienced a 34.55% reduction of hepatic encephalopathy. The placebo group experienced a 5.5% reduction.
WEAKNESS- Lacking physical strength or vigor marked by asthenia atony cardiasthena enervation fatigue and lassitude. The Liver Support group experienced an 83.45% decrease in the incidence of weakness while the placebo group reported no change.
ANOREXIA- Loss of appetite. Seen in depression malaise commencement of fevers and illness also in disorders of the alimentary tract especially of the stomach and as a result of alcoholic excess and drug addiction. Anorexia was diminished by 86.07% in the Liver Support group. There was no change in the placebo group.
TOTAL BILIRUBIN LEVEL - The predominant pigment of human bile. Total serum bilirubin may be increased in cirrhosis of the liver and acute viral hepatitis. The Liver Support group obtained 25.11% reduction in bilirubin whereas the placebo group had a 7.2% increase.
http://www.drugdigest.org/DD/PrintablePages/herbMonograph/0,11475,4129,00.html
In the United States, sarsaparilla is sold primarily as an oral remedy for skin conditions such as psoriasis. It is believed that chemicals in sarsaparilla may attach to endotoxins (the remnants of bacterial cells) that are common in individuals with psoriasis and certain other conditions. By eliminating or reducing the amounts of endotoxins in the body, sarsaparilla may help to relieve the condition.
Orally, sarsaparilla also has weak diuretic and laxative effects, which may make it useful in promoting the loss of excess water from the body and also in treating mild constipation. It may promote sweating, which may help to reduce fever. Sarsaparilla may also contain chemicals that act as a mild expectorant -- a substance that may loosen bronchial mucus and promote coughing. However, none of these effects have been verified through clinical studies and they may vary greatly depending on the amounts and type of sarsaparilla that is used.
Some anti-inflammatory effects associated with sarsaparilla made it useful in early medicine for treating arthritis and related conditions.
D-Glucarate - Increases Glucuronidation
http://www.lef.org/protocols/prtcl-143a.shtml
A phytoextract, D-glucarate, has been shown to support the glucuronidation pathway by inhibiting the activity of beta-glucuronidase. D-glucarate may be obtained naturally by emphasizing apples, grapefruit, broccoli, and brussels sprouts in the diet and by supplementing with calcium-D-glucarate and vegetable concentrates. According to data released from the University of Texas M.D. Anderson Cancer Center, D-glucarate inhibited beta-glucuronidase by 57% in the blood, 44% in the liver, 39% in the intestines, and 37% in the lungs, thus protecting the action of the glucuronidation pathway (Dwivedi et al. 1990).
PERSONAL: Gilberts Web Forums
Gilbert's Syndrome by Marina Eckel
Calcium D-Glucarate, a component of Tyler’s Detoxification Formula, works to prevent the action of beta-glucuronidase in the intestine. Beta glucuronidase enzymatically can deconjugate glucuronidation bound toxins, releaseing the toxins and allowing them to be reabsorbed in the intestines. {Ackerson, 312}. Blocking this action allows glucuronide-bound xenobiotics to be successfully eliminated from the body.
Creatine - Fatigue?
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=185.topic
neiltwy
I have recently started taking Creatine monohydrate as a training aid and many of the symptoms I had with GS seem to have either reduced in severity or gone altogether. I have also been taking an energy drink through sport and the whole training thing has become a joy.
http://www.drugs.com/mtm/creatine.html
• Creatine is produced naturally in the kidney, liver, and pancreas of humans. Creatine is also supplied in meat and fish. Most creatine in the body is stored in the muscles, in the form of phosphocreatine. Creatine is a quickly available source of energy for muscle contraction. Creatine is also involved in muscle growth.
• Creatine has been used to enhance athletic performance.
Digestive Enzymes - Digestive Problems
http://p075.ezboard.com/fgilbertswebfrm4.showMessage?topicID=5.topic
SumariMike
My main problem with GS seems to be digestion. I just have the worst time digesting food. I ate like I ate as a kid - lots of food, lots of gusto, who cares what I ate. I got fed up; felt like I was going to burst all the time. I always felt better taking an antihistamine with my food; curb the allergies. Finally, I went to a nutritionist to see what the hell was wrong with me. I did a fast for 3 days and nearly passed out at the end of it! Did 3 weeks of food allergy testing. Turned out I wasn't allergic to ANYTHING in small quantities. However, I had a lot of trouble digesting protiens. Too much would cause discomfort again. My nutritionist suggested digestive enzymes. THEY MADE ALL THE DIFFERENCE IN THE WORLD!! Someone on the original board mentioned this might be related to leaky gut syndrome.(different post) I take digestive enzymes with my meals. It's made me feel SO much better. The main point of this is to stem off food particles that are too large. If you don't break down all your food and you have holes in your intestines that allow those larger particles to get through (such as leaky gut syndrome), your body thinks that food is an invader. It sends the "invader" to the liver to be detoxified and eliminated from the body.
Here in Texas there's a store called Whole Foods. I believe you can even reach them via the web. The enzymes I take are called WholeZyme. They are in capsule form and contain the following ingredients: Bromelain (from Pineapple 120GDU), Papain (from papaya 600,000 FCCPU), Protease 3.9 (from aspergillus oryzae 10 SAPU), Amylase (from aspergillus oryzae 400 DU), Lipase (from Aspergillus niger 60 FCCLU), Protease 4.5 (from Aspergillus oryzae 400 HUT), Lactase (from Aspergillus oryzae 20 ALU), Cellulase (from Trichoderma longbrachiatum 10 CU), Hemicellulase (from Aspergillus niger 10 HCU).
Pancreatic Enzymes - Abdominal Pain
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=50.topic
TracyMWall
I have had terrible stomach discomfort for over one year. There have not been any "trigger" foods that made my eating experience more or less tolerable. After attempting to change my diet, take milk thistle, and exercise, I have found little comfort for this particular symptom of GS. Eating was a struggle, and most often I would end up sprawled out on a couch, unable to even touch my stomach and feeling extremely sick. This would last for several hours, result in tears, discomfort, and fatigue.Thankfully, I have consulted a nutritionalist who suggested I take Pancreatic Enzymes to aid the stomach in digestion. I bought them a day or two later, and take one (500 mg) tablet immediately after eating. I found INSTANT relief, and I now have very little discomfort after eating. I can consume three full meals a day, and as long as I take the enzyme tablet I feel GREAT!!
The only side effect I have from using these capsules is that I have heart burn symptoms afterwards. However, this problem is far less difficult to handle than the intense abdominal pain that I've lived with for over a year.
Protectiver - General
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=8.topic
petebray
I have since found something that works for me. I found a company called Neways that makes totally natural products, not tested on animals and they are led by some of the worlds top pharmicists. I started on a regime of three different products that are amazing but the one that really helps my liver is called Protectiver which has several natural derivetives in it (including Milk Thistle) which stimulate and protect the liver and stimulate bile production.
http://www.itsyourlife.uk.com/healthy_liver.html
Protectiver Ingredients (per tablet):
Vitamin A, Vitamin C, Vitamin E
Proprietary Blend 315.00 mg, Blessed Thistle, Dandelion Root, Milk Thistle Extract 70%
Amino Acids
Glutamine, Glycine, Taurine, Cysteine - Enzyme Support
http://www.liverdoctor.com/Section3/15_livertonics.asp
AMINO ACIDS
Specific amino acids are essential for the liver to break down toxins and drugs and also for the efficient metabolism of nutrients by the liver.Glutamine
This amino acid is required for phase two detoxification in the liver and is required in increased amounts by those who consume excessive alcohol. It is able to reduce the craving for alcohol. Glutamine supplementation is helpful for intestinal disorders such as peptic ulcers and leaky gut syndrome. Leaky gut is the term used to describe an inflamed condition of the lining of the bowel, which makes the bowel too permeable, so that toxins and incompletely digested food particles can be absorbed from the bowels directly into the liver. This increases the workload of the liver and may cause many health problems. Glutamine is used as fuel by the brain and by the lymphocytes (white blood cells). It is essential for the lymphocytes to fight viruses such as hepatitis B and C.Glutamine is converted in the body into glutamic acid, which, along with the amino acids cysteine and glycine, is converted into the powerful liver protector glutathione. Glutathione is essential for liver phase two conjugation reactions used during detoxification of drugs and toxic chemicals.
Glycine
This amino acid performs more biochemical functions than any other amino acids. It is required for the synthesis of bile salts, and is used by the liver to detoxify chemicals in the phase-two detoxification pathways.Taurine
Inadequate levels of taurine are common in those patients with chemical sensitivities, allergies and poor diets. Taurine is the major amino acid required by the liver for the removal of toxic chemicals and metabolites the liver to detoxify environmental chemicals such as chlorine, chlorite (bleach), aldehydes (produced from alcohol excess), alcohols, petroleum-based solvents and ammonia. Recent findings are demonstrating that taurine is one of the major nutrients involved in the body's detoxification of harmful substances and drugs, and should be considered in the treatment of all chemically sensitive patients. Taurine is helpful for fatty liver, high blood cholesterol and gall bladder problems, alcohol withdrawal, hepatitis and jaundice. Taurine is a sulphur bearing amino acid that is present in all good liver tonics for very good reasons. It is required for the healthy production of bile, and the liver uses it to conjugate toxins and drugs to excrete through the bile. It helps the liver to excrete excessive cholesterol out of the body through the bile, and thus is an aid to weight control and cardiovascular health. Doses required can vary from 50 to 2000 mg daily. It is free of side effects but should not be taken on an empty stomach in those with stomach ulcers. It is found in animal protein such as meat, seafood, eggs and dairy products but not in vegetable protein. Taurine is often deficient in strict vegans. Taurine regulates the transport of minerals across cell membranes and stabilises the electrical properties of cell membranes. For this reason, a deficiency of taurine has been linked to epileptic seizures, and combined with vitamin B 6, it has a useful anti-seizure effect in epileptics. It is made from two other amino acids methionine and cysteine.Cysteine
Cysteine is an amino acid that contains sulphur, and is needed by the phase-two detoxification pathway. It is a precursor of glutathione, which is needed to breakdown pollutants and toxins and has powerful antioxidant effects. Aldehydes, which are toxic breakdown products of alcohol, rancid fats and smog, are partially neutralized by cysteine. A study reported that large doses of acetaldehyde (derived from alcohol), killed 90% of the mice that consumed it. A control group of mice were primed with vitamin C, vitamin B 1 and cysteine, and were then given the equivalent amount of acetaldehyde that had killed 90% of the other mice. None of the supplement-primed mice in the control group died.
SAMe (S-Adenosylmethionine) & Methionine - Reduces Bilirubin, Estrogen, Increases Bile Transport, Enzyme Support, Mood
SCIENCE: National Library of Medicine
Effect of different doses of S-adenosyl-L-methionine (SAMe) on nicotinic acid-induced hyperbilirubinaemia in Gilbert's syndrome.
S-adenosyl-L-methionine (SAMe) has been shown to increase hepatocyte membrane fluidity thereby relieving signs of oestrogen-induced cholestasis. S-adenosyl-L-methionine might therefore prove effective in improving the efficiency of the transport of organic anions such as nicotinic acid (NA) and bilirubin which is impaired in Gilbert's syndrome (GS). In this study the effects on the metabolization rate of NA and bilirubin of two dosages of SAMe were evaluated in respect to placebo in ten male inpatients (mean age 24 years, range 16-31) with GS. Each patient received both SAMe (800 and 200 mg/day, respectively) and placebo treatment i.v. over a period of 10 days. The NA test (5.9 mumol/kg b.w. i.v.) was carried out in the same volunteers after each treatment. Unconjugated bilirubin (UCB) levels were significantly lower (p less than 0.01) after 800 mg/day SAMe than after placebo while the lower dosage of SAMe did not affect UCB values. The bilirubin time curve concentration, expressed as area under the curve (AUC), was significantly reduced (p less than 0.01) after 800 mg SAMe in comparison with the values obtained after placebo and 200 mg SAMe. Also plasma NA half-life was significantly reduced (p less than 0.01) by the higher dose of SAMe in respect to placebo and not by the lower dose.
In Short: SAMe has been shown to improve efficiency in transporting nicotinic acid (niacin) and bilirubin at 800mg/day. It also relieves signs of estrogen-induced cholestatis, a condition where bile cannot flow from the liver to the duodenum.
http://tuberose.com/Liver_Detoxification.html
Methylation involves conjugating methyl groups to toxins. Most of the methyl groups used for detoxification come from S-adenosylmethionine (SAM). SAM is synthesized from the amino acid methionine, a process which requires the nutrients choline, vitamin B12, and folic acid. SAM is able to inactivate estrogens (through methylation), supporting the use of methionine in conditions of estrogen excess, such as PMS. Its effects in preventing estrogen-induced cholestasis (stagnation of bile in the gall bladder) have been demonstrated in pregnant women and those on oral contraceptives. In addition to its role in promoting estrogen excretion, methionine has been shown to increase the membrane fluidity that is typically decreased by estrogens, thereby restoring several factors that promote bile flow. Methionine also promotes the flow of lipids to and from the liver in humans. Methionine is a major source of numerous sulfur-containing compounds, including the amino acids cysteine and taurine.
In Short: SAM also inactivates excess estrogen via methylation. Is S-adenosylmethionine (SAM) the same as S-adenosyl-L-methionine (SAMe)?
http://www.diagnose-me.com/cond/C319040.html
Methionine, administered as SAM, resulted in a significant decreases in serum bilirubin in patients with Gilbert's syndrome in a recent clinical study. SAM has been used with favorable results in a variety of other chronic liver diseases. TMG also converts to SAMe while being considerably less expensive.
http://www.diagnose-me.com/treat/T335931.html
Methionine is an essential amino acid which contains sulfur. It is found in animal products, and is important to control fat levels in the liver and the arteries. In the absence of high animal product intake, there is a danger of not getting enough methionine. This is the most common dietary deficiency seen in vegetarians.
Plant foods contain methionine as well: beans, seeds, onions, peanuts, lentils, and some grains. Methionine prevents fat build-up by assisting in the breakdown of fats; it detoxifies the digestive system; it is a powerful antioxidant; it reduces histamine levels; helps women excrete estrogen; helps to detoxify the liver.
Methionine, administered as SAM, resulted in a significant decreases in serum bilirubin in patients with Gilbert's syndrome in a recent clinical study. SAM has been used with favorable results in a variety of other chronic liver diseases. TMG also converts to SAMe while being considerably less expensive.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=57.topic
Tiger1976
I initially tried SAMe for 10 days at 400mg/day and then stopped since there was no visible improvement in my condition. A week later, I did some more research and found info on some web site that sold SAMe that SAMe should only be taken on an empty stomach and it should also be supplemented with Vitamin B-Complex. I started taking SAMe again early in the morning with B complex supplement and it's only been 7-8 days and I can definitely see an improvement. There is definitely some (little but noticable) white in my eyes that has not been there over the last 25+ years since I was diagnosed with GS. Today was the first day I went 800mg.
Me:
I got Nature Made brand SAMe about a month ago, thanks to suggestions on this site. I've been taking it here and there along with other supplements but not felt much of a difference. That is, until yesterday.
I decided to try the supplements all on their own, and yesterday was the day for testing SAMe. I discovered that I had only been taking a half-dose (200mg). It's worded strangely, but it appears you need to take 400mg (2 tablets) at ONCE. Well, I finally did this, and there was a marked positive effect. My mood improved, my brain fog subsided, music sounded better, and I became more outgoing and felt better overall. It was similar to the effect of Dextromethorphan, I thought, only about 1/3 as strong.
I've only tried the full dose this once, but based on how I felt (and still feel this morning), I highly recommend it.
Here's what it says on the box:
Quote:
SAM-e (s-adenosylmethionine) is a naturally occurring compound found in all living organisms. In humans, SAM-e is distributed throughout the body and is involved in many biochemical processes. Since significant amounts of SAM-e are not available through diet alone, the body is primarily responsible for producing its own SAM-e. Scientists know that SAM-e declines as people age and that certain groups of people, including those with low mood and liver conditions, tend to have lower levels of SAM-e in their bodies. Over 100 clinical studies involving thousands of people have proven that SAM-e supplementation benefits a multitude of body functions including:* Mood Support: Enhances mood by promoting a healthy balance of neurotransmitters, dopamine and serotonin, which are part of overall healthy brain cell functions.
* Joint Comfort: Promotes joint health by helping to maintain joint cartilage which naturally deteriorates with physical activity and age
* Liver Health: Helps support detoxification and overall healthy liver functions.Interesting to note that while I noted a similarity in effect with dextromethorphan, it turns out this ALSO helps improve dopamine and serotonin levels. Toss in the help with detox and this becomes very beneficial.
I still take hits in energy/discomfort/fog after I eat, but not quite as bad, and it doesnt last as long.
PERSONAL: Gilberts Web Forums
Gilbert's Syndrome by Marina Eckel
S-adenosylmethionine (SAM), an important physiological agent formed in the body by combining the essential amino acid methionine with adenosyl-triphosphate (ATP) has been shown to both activate several Phase II pathways (including glucuronidation) as well as promote bile flow and relieve cholestatis. {Pizzorno, 157} {Murray, 372}.
“Supplementation of 1 gram of SAM twice daily results in a significant decrease in serum bilirubin in patients with GS.” {Pizzorno, 157}
“Supplementation with SAM at a dosage of 400 mg three times daily has resulted in a significant decrease in serum bilirubin in patients with GS.” {Murray, 372}.SAM presents no significant side effects though individuals with bipolar (manic) depression should not take SAM as it may provoke a manic phase. {Murray, 372}.
A deficiency of methionin, vitamin B12, or folic acid can result in decreased SAM synthesis {Murray, 365}, therefore it is important that individuals eat whole foods to ensure a full range of nutrients.
TMG (Trimethylglycine) / Betaine - Reduces Bilirubin, Estrogen, Increases Bile Transport, Enzyme Support, Mood
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=85.topic
squid
I recently read on a website that TMG (me: Tri Methyl Glycine) was good for gilberts syndrome, i did some more searching and found some interesting things.TMG helps in the production of sam-e which has been mentioned on this board.
http://www.arrowheadhealthworks.com/TMG.htm
"Liver Disorders: As a part of liver-healing and protection formulas. Increases SAM levels in the liver, enables the liver to metabolize fat and protect against many challenges such as alcohol induced cirrhosis. TMG will also decrease BILIRUBIN, alkaline phosphotase, and several other liver enzymes related to a large variety of liver disorders. Significant liver benefits have been shown in 20 studies. Dose range: 500-1,500 mg. daily."
www.wizardofeyez.com/tmg.html"Trimethylglycine (TMG) is an excellent source of methyl groups and is found in good quantities in broccoli and beets."
"Methylation increases production of S-adenosyl-methionine, or SAMe. "
"Research shows that decreased methylation is involved in many health conditions, including diseases of the cardiovascular system, brain and liver, as well as cancer"
"SAMe is very useful in liver disease and in osteoarthritis it has been shown to stimulate cartilage regeneration."
"When SAMe is spent, it loses a methyl group to become homocysteine. TMG recycles the homocysteine back into SAMe, so with enough TMG in the system, the same SAMe molecule can be used over and over"
http://www.digitalnaturopath.com/treat/T36297.html
"TMG is a versatile nutrient and provides an intermediary metabolite that can enable a person or animal to function at more optimum mental and physical levels"
and also there has been discussion of:
"Chronic fatigue syndrome: Greater mental alertness and energy, improves immune dysfunction."TMG is also thought to increase liver enzyme function and increase muscle growth ( GS is meant to make you weak)
sounds like broccoli is the new GS wonder drug.
Matthew2002
I've been on it (TMG) for almost a month now and I feel more alive than ever! It slighty reduced the yellow tint to my eye which is hard to notice now. I have been on it for well over 2 1/2 weeks. I've been taking 3-4 500mg pills a day.http://www.nutritiondome.com/nutritiondome1/jartmgtrimet.html
I am still taking TMG (500mg) 6 tablets a day. Still slight jaundice in the eyes but I feel good.
DaveH439
After reading about TMG I decided to try it. The only product I could get locally was called "Connect" produced by Natural Highs and contained TMG together with a number of other things like B6 & B12. After the first couple of days I felt less of the fatigue and brain fog and I noticed I got a much better restful sleep. It's early days but I have been encouraged by the very quick result I have got with this productrhlhmhkh
I have tried St. John's wort, Seasilver, SAMe and have had NO relief until now. I have been on Tri Methyl Glycine for the last 2 weeks and feel better than I have felt is over a year. I sure hope I continue to feel this good. (later) I tried it for a few of months and unfortunately, I did not find that it helped. I was hoping it was the miracle I am searching for. The fatique I have is unbearable some days. While taking TMG, I felt better some days and thought it was working then I would get an incredible low even while taking it.StevieRay2
I have been taking TMG for the past 3 weeks and I must admit that my eyes are less yellow. Certainly not what I would consider normal white, but definitely an improvement. I have been taking three 750 mg tablets daily - but I am thinking of upping the dosage to four tablets per day.(later) I am taking TMG - 6 x 500 daily - but gave up on milk thistle long ago after I determined that it did nothing for me. TMG seems to have reduced the yellow color of my eyes - but I would suspect that my billirubin level remains higher than normal since my eyes are still slightly yellow. The TMG I have been taking also includes folic acid, and vitamins B6 and B12, and I have also been supplementing with vitamin C... For me, TMG has produced no physical effects other than somewhat reducing the yellow color of my eyes. I am hoping to experience continued improvement after several months of "liver cleansing" if that's what the TMG is doing.
martinlong1978
I've tried TMG... first the dose on the bottle...3x500 a day. Useless, but when I upped the dose to 6x500 a day - fantastic. You still have to watch what you drink etc, but it can hel you live a normal life.dmy222
How long taking TMG before an effects were felt, i started taking but made me feel tired,StatenBoy
I have tried sjw, and tmg, but I did not have any luckKotulc
I think that TMG works realy well. I'm taking it for 4 days and I must say, I fell much, much better.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=158.topic
squid
i have managed to impove my gilberts like symptoms 100%... One of the most effective things for improving my health i have found is Raw spinach. Since i started eating it i feel calmer happier and more alert.Cooking removes around 80% of vitamins and minerals as well as digestive enzymes from food. This is why spinach beets broccoli for TMG.
"The Biochemistry of Homocysteine
There are three biochemical pathways used by the body to reduce homocysteine. In one pathway, TMG donates a methyl group which detoxifies homocysteine. In this reaction, TMG is turned into dimethylglycine (DMG) - yes, that familiar product sold as a supplement for its energizing effects. In the other routes, folic acid, B12 and B6 convert homocysteine into non-toxic substances."Spinach contains B6 and folic acid. B12, as vegetarians will tell you, you can get from microorganism on the surface of green vegetables (such as spinach).
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=155.topic
SxSnipeR
Trimethylglycine = Betaine in the UK
Uk preparations - None with betain on its own
in combination = Quest Enzyme Digest with betaine HCL
and DigenzymeThe ingredients are as follow: Microcrystalline Cellulose, Betaine HCL, Amylase, Lipase, Bromelain, papain, Magnesium Stearate, Sillicon Dioxide, Peppermint Oil.
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=104.topic
DaveH439
I have started taking a product containing TMG. Early days but the initial thoughts have been good. I have also noticed that since taking this product my reaction to the foods that normaly zap my energy has been very much improved and I seem to be able to tolerate them without the normal bad reaction.
NAC (N-Acetyl-Cysteine) & Glutathione - Enzyme Support, Anxiety
http://www.liverdoctor.com/Section3/15_livertonics.asp
Glutathione
Glutathione is a potent antioxidant that is produced in the healthy liver where it neutralizes oxygen molecules before they can damage cells. Glutathione is a component of the antioxidant enzyme glutathione-S-transferase, which is a widely acting liver-detoxifying enzyme. Indeed large amounts of glutathione are stored in the liver, where it detoxifies harmful compounds so they can then be excreted via the bile. Glutathione helps to reduce damage from cigarette smoke, alcohol, radiation, heavy metals, drugs and chemotherapy. Glutathione plays a vital role in preventing liver cancer. Glutathione levels decline with age, and this may accelerate the ageing process. It is not worth taking glutathione supplements, as they are expensive and usually poorly absorbed. It is far more effective to increase glutathione levels by giving the liver, the raw materials it needs to make its own glutathione, namely, the amino acids glycine, glutamine and cysteine.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=13.topic
jeelbear
The increasing glutathione with food products absolutely is remarkable for the symptoms though, especially anxiety. Try broccoli and walnuts too at least every other day and see if it doesn't help the racing heart/pulse rate. If I get that racing heart feeling I eat one half cup of broccoli and it disappears. It also gets rid of that bloated feeling.
http://p075.ezboard.com/fgilbertswebfrm1.showMessage?topicID=15.topic
Trinityonline
At the moment I take N-Acetyl-Cysteine(NAC) which produces a very strong antioxidant, Glutathione which is already in the liver, but if you suffer with an impaired liver it needs as much help as it can get!
http://p075.ezboard.com/fgilbertswebfrm1.showMessage?topicID=140.topic
Trinityonline
I started taking NAC (N-Acetyl-Cysteine), which I noticed you havn't tried, you can get it from most health shops (if you live in the UK sellected Holland and Barret stores sell it). NAC is an amino acid that is a precursor to Glutathione, which is a strong antioxidant that is excellent for phase 2 detoxification of the liver, (Milk thistle being phase 1 detoxification). After a week of taking it (600mg), my urine was more yellow which I believe is my liver getting rid of the toxins instead of pumping it round the body, due to this my face hasn't gone yellow for a few weeks, and my eyes aren't as bad.
I forgot to add to my previous message, if NAC is taken, twice the amount of vitamin C needs to be taken also, so if 600mg NAC is taken 1200mg of vitamin C needs to be taken also. This is because NAC oxidises vitamin C so supplements are required!!
http://p075.ezboard.com/fgilbertswebfrm4.showMessage?topicID=31.topic
TrinityOnline
(me: regarding acne) I never normally suffer, just the occasional one, but since taking mainly NAC (N-Acetyl-Cysteine), I've broken out!!
http://www.lef.org/protocols/prtcl-143a.shtml
Glutathione
If entry of noxious materials is not controlled, detoxification, a cleansing ritual, can no longer keep pace, and alternative measures to encourage detoxification should be employed. Many nutrients and therapies assist in detoxification but glutathione is particularly important since it contributes to both Phase I and Phase II detoxification mechanisms. According to Eric R. Braverman, M.D., glutathione lessens the toxicity of heavy metals, automobile exhaust, cigarette smoke, fungicides, herbicides, nitrates, solvents, plastics, detergents, insecticides, and drugs. Furthermore, repeated exposure to any of these toxins can deplete glutathione faster than it can be produced or absorbed. Vitamin C appears to be an excellent nutrient to increase glutathione stores by stimulating the rate of glutathione synthesis. Glutathione supplementation is also available for individuals not wishing to rely upon vitamin C for glutathione enhancement. Glutathione in 250-mg capsules, taken on an empty stomach 1 or 2 times daily, is the recommended dosage.
Amino2000 - Enzyme Support
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=52.topic
mariusz
natural amino acids eg. “Amino 2000”-Ultimate Nutrition Corporation ( you can buy it in stores with body building supplements). It gets what we need: glutamine, glycine, taurine, cysteine, methionine etc. It is wanderful to give you a lot of energy and a little lower bilirubin.
Vitamins
Vitamin C - Enzyme Support
http://www.liverdoctor.com/Section3/15_livertonics.asp
Vitamin C is the most powerful antioxidant vitamin for the liver and reduces toxic damage to the liver cells from chemical overload. It neutralizes free radicals generated during the phase 1 detoxification pathway in the liver. Toxic chemicals are far less dangerous if there is plenty of vitamin C in the liver. It helps the liver to regulate cholesterol levels and improves immunity.
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=48.topic
parkin98
Also about a third of a soluble vitamin C tablet helps me if I feel especially tired, particularly if I have a Red Bull-style energy drink at the same time.
PERSONAL: Gilberts Web Forums
Gilbert's Syndrome by Marina Eckel
Vitamin C functions to activate the glucuronidation pathway {Bland, 10} and should be supplemented on a regular basis. Exact ranges to be determined by a nutrition consultant.
Vitamin E - Antioxidant
http://www.liverdoctor.com/Section3/15_livertonics.asp
Natural vitamin E is biologically more active than synthetic vitamin E. Vitamin E is a powerful antioxidant that protects fats from damage. Since cell membranes are composed of fats, vitamin E is the best protector of cell membranes. It does this by preventing free radicals from oxidizing cell membranes, which prevents them from becoming rancid. Thus vitamin E can help to protect the membranes surrounding liver cells. Vitamin E is also needed in those with a "fatty liver", where there is an accumulation of unhealthy oxidized fats in the liver cells.
Vitamin B2 / Riboflavin - Nausea?
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=77.topic
azvessey
suffered from nausea for all of those 30 years until just recently when I grabbed an old bottle of Vit. B2 that had been sitting in the cupboard for two years. Instant cure!
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=102.topic
Azvessey
what does work for me is 50mg+ of riboflavin (Vit. B2) per day. This is normally adequately supplied by milk and cheese, among other foods, but if you suffer from IBS or malabsorption this may help.
Vitamin B Complex - Fatigue, Nausea, Stomach Cramps, Anxiety, Bloating, Carbohydrate Processing, Metabolism, Immune Enhancer
Be aware that Vitamin B Complex vitamins probably contain Vitamin B3 (Niacin), which raises bilirubin levels. A B-complex vitamin lacking B3 would be ideal. However, it's been said that Niacin has a reduced effect on bilirubin when taken with other B-vitamins.
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=3.topic
TheWojak
I have found that taking 2 Vitamin B Complex Vitamins (Natural not synthetic ... I prefer Shaklee's) every 4 days keeps the cramping and nausea away. It also gives me more energy. I came across this by researching something that was given me while hospitalized ... Berocca.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=26.topic
macpgh
A 'B'complex vitamin tab will also aid in getting energized again, as this is depleted in stress conditions.
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=59.topic
stmacrina
GS & severe PMS since I started mensturating at age 11... I've found the benefits B-vitamins for taking the edge off the anxiety and the water retention.
http://en.wikipedia.org/wiki/Vitamin_b
List of B vitamins
• Vitamin B1 (Thiamine)
• Vitamin B2, (Riboflavin)
• Vitamin B3, also Vitamin P or Vitamin PP (Niacin)
• Vitamin B5 (Pantothenic acid)
• Vitamin B6 (Pyridoxine and Pyridoxamine)
• Vitamin B7, also Vitamin H
• Vitamin B9, also Vitamin M and Vitamin B-c (Folic acid) - important for pregnancies
• Vitamin B12 (Cyanocobalamin)The B vitamins often work together to deliver a number of health benefits to the body. B vitamins have been shown to:
• Bolster metabolism
• Maintain healthy skin and muscle tone
• Enhance immune and nervous system function
• Promote cell growth and division — including that of the red blood cells that help prevent anemia.
Together, they also help combat the symptoms and causes of stress, depression, and cardiovascular disease.
All B vitamins are water soluble, and are dispersed throughout the body and must be replenished daily with any excess excreted in the urine (which turns a bright yellow color).Vitamin B comes from a number of natural sources, including potatoes, bananas, cereal, lentils, chili peppers, tempeh, liver, turkey, and tuna. Nutritional yeast (or Brewer's yeast) is an especially good source of Vitamin B.
http://home.howstuffworks.com/vitamin-b.htm
Both the B vitamins and vitamin C are also stored in the liver.
The B-complex vitamins are actually a group of eight vitamins, which include thiamine (B1), riboflavin (B2), niacin (B3), pyridoxine (B6), folic acid (B9), cyanocobalamin (B12), pantothenic acid and biotin. These vitamins are essential for:
• The breakdown of carbohydrates into glucose (this provides energy for the body)
• The breakdown of fats and proteins (which aids the normal functioning of the nervous system)Thiamine (B1)
The B vitamin thiamine is essential for the metabolism of carbohydrates into the simple sugar glucose. The chemical process involves the combination of thiamine with pyruvic acid to form a coenzyme, a substance that, when combined with other substances, forms an enzyme. Enzymes are those all-important proteins that speed up chemical reactions in the body. Thiamine is also important for the proper functioning of the nervous system. In this instance, thiamine acts as a coenzyme in the production of the neurotransmitter (chemical messenger between nerve fibers) acetylcholine.
Thiamine deficiency is rare but often occurs in alcoholics, because alcohol interferes with the absorption of thiamine through the intestines. There are several health problems associated with a deficiency of thiamine. The first is beriberi, a disease that is characterized by anemia, paralysis, muscular atrophy and weakness, and spasms in the muscles of the legs. Other disorders caused by thiamine deficiency include Wernicke's encephelopathy, which causes lack of coordination, and Korsakoff's psychosis, which affects short-term memory. The mouth can also be affected by thiamine deficiency, increasing the sensitivity of the teeth, cheeks and gums, as well as "cracks" in the lips. Fortunately, these conditions can be reversed with the addition of the vitamin.
Note: This could be the connection to the carb intolerance seen pretty frequently with Gilbert's Syndrome. Also, anemia, weakness, short-term memory.
Riboflavin (B2)
Riboflavin is important in the breakdown of carbohydrates, fats and proteins, and, like thiamine, it acts as a coenzyme in the process. It is also significant in the maintenance of the skin and mucous membranes, the cornea of the eye and for nerve sheaths. Riboflavin also acts as a coenzyme for oxidation-reduction reactions throughout the body. Oxidation reduction reactions involve the addition of either oxygen or hydrogen to a substance. One important consequence of this process is when it acts to inhibit chemical reactions with oxygen or highly reactive free radicals. These oxidation reactions can cause damage to our cells. (See How Cells Work.)
A deficiency of riboflavin can cause skin disorders (seborrheic dermatitis) and inflammation of the soft tissue lining around the mouth and nose, anemia, and can cause the eyes to be light-sensitive. In the mouth, angular cheilosis can develop. This is a painful condition where lesions develop at the corners of your lips, and glossitis (inflammation of the tongue) can also occur.
Note: More carbohydrate links. Also seborrheic dermatitis (which I have), anemia, and light sensitivity.Niacin (B3)
Niacin, also known as nicotinic acid and nicotinamide, is needed for the metabolism of food, the maintenance of healthy skin, nerves and the gastrointestinal tract. Niacin is also used in those all-important oxidation reduction reactions. A deficiency of niacin causes the disease, pellagra. In the past, this disease was often associated with the very poor and was also a major cause of mental illness. The symptoms of pellagra are sometimes referred to as the "three D's" -- diarrhea, dermatitis and dementia -- ultimately resulting in a fourth "D", death. The mouth is also affected by pellagra, which can cause the inside of the cheeks and tongue to become red and painful. Fortunately, high doses of niacin (150-300 mg.) can reverse the effects of this disease.
Pyridoxine (B6)Pyridoxine, also known as pyridoxal phosphate and pyridoxamine, is needed (like some of the other B vitamins) for the breakdown of carbohydrates, proteins and fats (see How Fat Works.) Pyridoxine is also used in the production of red blood cells (see How Blood Works), as well as in the biochemical reactions involved in the metabolism of amino acids (the building blocks of protein). Due to the abundance of pyridoxine in many foods, a deficiency is rare except in alcoholics, where it is often present. A pyridoxine deficiency causes skin disorders (similar to symptoms brought on by riboflavin and niacin deficiencies), neuropathy (abnormal nervous system), confusion, poor coordination and insomnia. Oral signs of pyridoxine deficiency include inflammation of the edges of the lips, tongue and the rest of the mouth.
Cyanocobalamin (B12)Vitamin B12 is necessary for processing carbohydrates, proteins and fats and to help make all of the blood cells in our bodies. Vitamin B12 is also required for maintenance of our nerve sheaths. Vitamin B12 acts as a coenzyme in the synthesis and repair of DNA.
Vitamin B12 cannot be absorbed or used by the body until it is combined with a mucoprotein made in the stomach and called intrinsic factor. Once the B12 becomes bound to the intrinsic factor, it is able to pass into the small intestine to be absorbed and used by the body. Vitamin B12 deficiency is sometimes seen in strict vegetarians who do not take vitamin supplements, and those who have an inability to absorb the vitamin (usually from a failure to produce intrinsic factor). Although enough B12 is stored in the liver to sustain a person for many years, a deficiency will cause a disorder known as pernicious anemia. Pernicious anemia causes weakness, numbness of the extremities, pallor, fever and other symptoms. Mouth irritation and brain damage are also common consequences of B12 deficiency. However, these very serious effects can be reversed by vitamin B12 shots. Shots are needed because the deficiency is often caused by an inability to absorb the vitamin when taken orally. As we age, our stomachs have an increasingly difficult time producing intrinsic factor. Many doctors recommend that people over 60 have their vitamin B12 levels checked, to see if a B12 shot is needed.
Folic acid (B9)
Folic acid, also known as folacin and pteroylglutamic acid, is one of the B-complex vitamins that interacts with vitamin B12 for the synthesis of DNA, which is important for all cells in the body. Folic acid, in combination with vitamin B12 and vitamin C (see also How Vitamin C Works), is necessary for the breakdown of proteins and the formation of hemoglobin, a compound in red blood cells that transports oxygen and carbon dioxide. Folic acid is also essential to virtually all biochemical reactions that use a one-carbon transfer and is produced by bacteria in the stomach and intestines.
A deficiency of folic acid causes anemia, poor growth, and irritation of the mouth -- all of which are similar to symtoms suffered by those with B12 deficiency. Folic acid is present in nearly all natural foods but can be damaged, or weakened, during cooking. Deficiencies are found mainly in alcoholics, the malnourished, the poor, the elderly and those who are unable to absorb food due to certain diseases (topical sprue, gluten enteropathy).
Pantothenic acid and biotin
Pantothenic acid is used in the breakdown of carbohydrates, lipids and some amino acids. It is also used for the synthesis of coenzyme A for biochemical reactions in the body. Biotin functions as a coenzyme in carboxylation reactions (-COOH), which are also useful in many of the body's functions. (Pantothenic acid, biotin and folic acid are often used in tandem by the body.) Bacteria in our intestines produce both pantothenic acid and biotin. There is no known disorder associated with pantothenic acid deficiency. The vitamin is found in abundance in meats, legumes and whole-grain cereals. Mega-doses of pantothenic acid can cause diarrhea.
A deficiency of biotin is rare but can cause a skin disorder called scaly dermatitis.
http://www.netfit.co.uk/vit3.htm
Pantothenic Acid (B5)
Has an enhancing effect upon the adrenal glands, and is often taken during stressful conditions. It is also necessary during metabolism of fats, carbohydrates and proteins. Helps form certain hormones and antibodies.
Minerals
Zinc Salts - Zinc Gluconate, Zinc Acetate, Zinc Sulfate - Reduces Bilirubin
Supplemental Zinc Salts: Orazinc, Verazinc, Zinc 15, Zinc Gluconate, Zinc Sulfate, Zincate, Zinc Methacrylate, Zinc Acetate
The effect of zinc salts on serum bilirubin levels in hyperbilirubinemic rats.
RESULTS: Substantial bilirubin-binding activities of zinc salts were demonstrated in in vitro experiments. Treatment with oral zinc salts significantly decreased serum bilirubin levels in Gunn rats (166 +/- 53 versus 123 +/- 38 and 206 +/- 34 versus 131 +/- 31 micromol/L, P < 0.05 for zinc methacrylate and zinc sulfate, respectively). A similar effect of zinc methacrylate was also observed in hyperbilirubinemic Wistar rats (102 +/- 10 versus 14 +/- 4 micromol/L, P < 0.0001). In accord, biliary bilirubin secretion decreased significantly in these animals (45 +/- 11 versus 28 +/- 4 nmol/h 100g body weight, P < 0.02). In contrast to zinc sulfate, treatment with zinc methacrylate did not lead to the elevation of serum zinc levels.
SCIENCE: National Library of Medicine
Zinc sulfate inhibits the enterohepatic cycling of unconjugated bilirubin in subjects with Gilbert's syndrome.
We have previously observed that UCB binds to ZnSO4 in vitro, and suppressed the biliary bilirubin secretion in the hamster. The aim of this study was designed to investigate whether Zn salts might inhibit the enterohepatic cycling of UCB in subjects with Gilbert s syndrome. Fifteen patients with Gilbert s syndrome and 5 normal healthy volunteers were included in this study according to the following criteria: fasting hyperbilirubinemia, no hemolysis, and free of any medication. Patients were randomly assigned to receive acute or chronic treatment. Subjects treated in acute form and normal healthy volunteers were treated with 40 mg of ZnSO4 in a single dose, where as patients treated in chronic form received 100 mg ZnSO4 in a single dose daily for 7 days. The serum UCB levels (mg/dL) decreased from 2.64 +/- 1.04 to 2.02 +/- 0.87 (p < 0.001) and 1.8 +/- 0.36 to 1.48 +/- 0.32 (p < 0.005) in subjects treated in acute and chronic form respectively, but not in the control group. Whereas, the serum Zn levels (mg/dL) increased from 96.3 +/- 16.8 to 118.8 +/- 19. 5, (p < 0.01) and from 117.6 +/- 8.5 to 130.7 +/- 6.6 (p < 0.03) in subjects treated in acute an chronic form and also in subjects in the control group (98.0 +/- 7.3 to 128.0 +/- 21.9) p < 0.03. This study showed that acute and chronic oral administration of ZnSO4 decreased serum UCB levels significantly in subjects with Gilbert s syndrome. Most likely by the inhibition of the "normal" enterohepatic cycling of UCB.
In Short: Zinc sulfate binds to unconjugated bilirubin and therefore decreases the levels circulating.
Me:
I took this in the form of 50mg Zinc Sulfate Monohydrate, which it said was the equivalent of 220mg Zinc Sulfate Heptahydrate. Within an hour I felt an uncomfortable burning feeling in my heart area which is still there 12 hours later. There is also a slight increase in clarity and energy. But not enough to recommend this. Perhaps the dose was too high? Or the forumlation wrong? I did not like the heartburn feeling. I'll consult a physician about this.
A therapist at Walgreens told me that "Zinc sulfate 220 mg contains 50 mg of elemental zinc. The associated monohydrate or heptahydrate does does alter the strength of zinc sulfate, or elemental zinc. There is no difference in the side effects of zinc sulfate, zinc sulfate monohydrate, or zinc sulfate heptahydrate."
http://www.drugs.com/MTM/zinc_sulfate.html
Before taking zinc sulfate, talk to your doctor if you are taking
• a tetracycline antibiotic such as tetracycline (Sumycin, Achromycin V, and others), demeclocycline (Declomycin), doxycycline (Vibramycin, Monodox, Doxy, and others), minocycline (Minocin, Dynacin, and others), or oxytetracycline (Terramycin, and others); or
• a fluoroquinolone antibiotic such as ciprofloxacin (Cipro), ofloxacin (Floxin), enoxacin (Penetrex), norfloxacin (Noroxin), sparfloxacin (Zagam), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), gatifloxacin (Tequin), trovafloxacin (Trovan), and others.Zinc sulfate may decrease the absorption of the antibiotics listed above. You may not be able to take zinc sulfate, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
http://www.medicinenet.com/zinc_sulfate-oral/article.htm
USES: This medication is a mineral used to treat or prevent low levels of zinc.
OTHER USES: This medication may also be used to promote wound healing.
HOW TO USE: Take this medication by mouth as directed by your doctor or on the package. Take this medication 1 hour before or 2 hours after meals. May be taken with food if it upsets your stomach. Best to swallow whole. Do not crush or chew. Avoid milk, bran, grains, or cereals within 2 hours of taking this medicine. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day.
SIDE EFFECTS: Nausea, stomach upset, heartburn may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
PRECAUTIONS: This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: low blood levels of copper.
SCIENCE: National Library of Medicine
Zinc sulfate inhibits the enterohepatic cycling of unconjugated bilirubin in subjects with Gilbert's syndrome.
We have shown in our in vitro studies that Zn sales at physiological pH and above adsorb UCB essentially completely from unsaturated BS micellar solutions. This indicates that there is a physico-chemical interaction between UCB and Zn salts. The interation probably is via the carboxyl groups of UCB, as occurs with other divalent cations such as Ca2+ leading to the formation of calcium bilirubinate [Ca(BH)2].
Zn is the least toxic of the trace metals.
Interestingly, Dashti et al observed in experimental liver cirrhosis produced by thioacetamide that zinc sulfate-treated animals showed a restoration of normal hepatic and plasma zinc and copper levels plasma. Similarly, plasma levels of aspartate animotransferase, alanine aminotransferase, gamma-glutamyl aminotransferase, and total bilirubin decreased significantly. Light microscopic studies showed that most of the hepatocytes appeared normal in zinc-treated as compared with untreated cirrhotic animals.
http://www.mayoclinic.com/health/drug-information/DR202622
When zinc combines with certain foods it may not be absorbed into your body and it will do you no good. If you are taking zinc, the following foods should be avoided or taken 2 hours after you take zinc:
• Bran
• Fiber-containing foods
• Phosphorus-containing foods such as milk or poultry
• Whole-grain breads and cerealsDo not take zinc supplements and copper, iron, or phosphorus supplements at the same time. It is best to space doses of these products 2 hours apart, to get the full benefit from each dietary supplement.
Although this use is not included in product labeling, zinc supplements are used in certain patients with the following medical condition:
• Wilson's disease (a disease of too much copper in the body)
Potassium - Palpitations, Anxiety, Muscle Twitching, Fatigue, Dizziness, Leg Pain
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=218.topic
mouscelia
Has anyone else had problems with either of these things? I recently found out that I have low potassium levels...which was causing palpitations, anxiety, a flare up of GS and muscle twitching. I am now taking 20 milli-equivalents of potassium chloride daily. I noticed it is helping my fatigue and spacey feelings. I also noticed on the homepage of this site where it says what to eat for GS, a lot of those foods are high in potassium. I wonder if that is a coincidence or if there is a connection.
http://p075.ezboard.com/fgilbertswebfrm2.showMessage?topicID=24.topic
SumariMike
If you are experiencing dizziness either on a low-carb diet or in general, find out if your potassium is low. People with low potassium also report leg achiness/pain and sluggishness. A potassium supplement corrects this very quickly. If you are taking blood pressure medicine or are advised against it, don't take potassium supplements w/o checking w/your doc because some medications force potassium to stay in the body and you can cause trouble by having too much. Low carb diets cause an increase in urination the first week or two and you lose salts, including potassium quickly.
Chromium Picolinate - Carbohydrate Processing
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=26.topic
macpgh
I have chronic fatigue syndrome, and in some people there is an expression of depression with this condition.For people with dietary problems, you should take a dose of chromium picolinate. It is usually sold as the proper dose in a single pill, something like 200micrograms. This form of the mineral helps with insulin utilization within the body, and is typically stripped out in the regular american diet. So if your a high carb person, this is for you. In the over all view of the human biologic system, the sugar is transformed into glycogen & stored in the muscles for instant energy upon exersion. If mysterious forces upset this mechanism, this mineral should help you get reset. Fatigue is more the component of exercersion of muscles past normal limits, malaise is the dreaded sickly feeling. They shouldn't go hand in hand together, and the liver is the organ that gets over taxed from all aspects of life & these 2 items are main factors other than pushing it with the ingestion of toxics other than alcohol.
http://p075.ezboard.com/fgilbertswebfrm3.showMessage?topicID=63.topic
SumariMike
I started taking these vitamins to supplement since low-carb diets are also low in nutrients: Multivitamin, Calcium-Magnesium, Potassium (you get light-headed when you are on low-carb diets because your potassium evacuates quickly), Chromium picolinate (helps mobilize fats/carbs).
Antioxidants
Natural Carotenoids - Antioxidant
http://www.liverdoctor.com/Section3/15_livertonics.asp
Natural Carotenoids
Carotenoids such as betacarotene are most commonly found in fruits and vegetables and are most significant for human health. It is important to take only natural sources of beta-carotene and other carotenoids. Beta-carotene gets converted in the body to vitamin A and yet has none of the toxic side effects of high doses of vitamin A. Large population studies have shown that low intakes of beta-carotene are associated with a higher incidence of cancer. Beta-carotene is a powerful protective antioxidant.
Recreational Drugs
Marijuana - Nausea
Marijuana is one of the best known cures for nausea. However, it is illegal in many places. If you have access to medical marijuana, it would probably help a great deal with nausea. The smoke from smoking it can cause problems with the linked UGT1A7 mutation. You can avoid this effect by properly preparing and ingesting it.
http://p075.ezboard.com/fgilbertswebfrm4.showMessage?topicID=110.topic
lildvez
I smoke pot for the nausea and occasional headaches because that is really the only thing that helps me.
Herbs
Yin Chen / Capillary Wormwood / Artemisia Capillaris - Reduces Bilirubin
Yin Chen is the active herb in the Chinese tea Yin Zhi Huang which reduces bilirubin levels. Yin Chen is inexpensive and available in its pure form from some online Chinese Herbalists.
http://news.bbc.co.uk/2/hi/health/3363223.stm
Chinese tea 'may cure jaundice'
Scientists in the United States have found that Yin Zhi Huang (YZH) can stop the build-up of a type of bile that causes the condition.Dr David Moore and colleagues at Baylor College of Medicine in Houston, Texas, found that the tea activates a key receptor in the liver.
This enables the liver to clear bilirubin - a waste product that is created from the break down of haemoglobin, a substance in red blood cells that carries oxygen around the body.
http://www.pubmedcentral.gov/articlerender.fcgi?artid=300765
A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR
Yin Zhi Huang, a decoction of Yin Chin (Artemisia capillaris) and three other herbs, is widely used in Asia to prevent and treat neonatal jaundice. We recently identified the constitutive androstane receptor (CAR, NR1I3) as a key regulator of bilirubin clearance in the liver. Here we show that treatment of WT and humanized CAR transgenic mice with Yin Zhi Huang for 3 days accelerates the clearance of intravenously infused bilirubin. This effect is absent in CAR knockout animals. Expression of bilirubin glucuronyl transferase and other components of the bilirubin metabolism pathway is induced by Yin Zhi Huang
Yin Zhi Huang contains extracts from four different plants: Artemisia capillaris, Gardenia jasminoides Ellis, Rheum officinale Baill, and Scutellaria baicalensis Georgi.
Bilirubin is highly hydrophobic, and chronic hyperbilirubinemia results in its deposition in the central nervous system, causing neurotoxicity and encephalopathy. Some evidence suggests that chronic jaundice may also suppress the immune system as well as other normal physiological functions (4, 5).
CAR coordinately regulates the bilirubin clearance pathway. In addition to its function as a xenobiotic receptor, CAR responds to elevated levels of bilirubin by increasing the hepatic clearance of this toxic endobiotic (24)… Yin Zhi Huang stimulation of bilirubin clearance is dependent on CAR. The primary role of CAR in bilirubin metabolism is consistent with earlier studies showing positive effects of phenobarbital on jaundice (37, 38).
Yin Chin alone is considered to be the major active herb in the Yin Zhi Huang mixture.
6,7-Dimethylesculetin activates both mouse and human CAR. These results indicate that Yin Chin contains an agent or agents that can activate both mouse and human CAR. Among a number of compounds present in Yin Chin are the coumarin 6,7-dimethylesculetin (scoparone) and 4′-hydroxyacetophenone (Figure 4a). 6,7-Dimethylesculetin is a major constituent, comprising up to 2% of Yin Chin by dry weight and has been associated with a number of potential biologic actions (40).
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SumariMike
http://www.mcmia.org/index.asp?Page=content&Lang=EN&doc_id=306This article is one connected to something I found on PubMed Central where it is proven that a Chinese herbal tea can help stimulate bilirubin clearance from the system. I read the "easy to read" paper here:
http://www.pubmedcentral.gov/articlerender.fcgi?artid=300773
I'm going to go find some. It appears to significantly clear the bilirubin liver pathways, even more than phenobarbitol without all the side effects.
Although the articles don't mention GS specifically, they discuss the UGT1A transfer pathways, hyperbilirubinemia, and the common jaundice in infants as a result of poor bilirubin conjugation. All the other GS articles refer to these same areas.
Here's another good easy-to-read link about the effects of Yin Zhi Huang:http://www.sciencenews.org/articles/20040228/food.asp
Here's the only place I can see that sells it, and sells it in "granule" form. I sent an e-mail to the person listed on the site:
www.lunan.com.cnHere's an interesting historical description of Yin Zhi Huang, which MAY be what is called "Wormwood" in America:
http://www.botanical.com/botanical/mgmh/w/wormwo37.html#commed
It shows that Wormwood helps cure the yellowing of people. Wormwood is apparently related to Absinthe, so be careful.
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Yates66
The article states thier confident Yin Chin will clear bili by itself. I have tried Yin Chen Hao or (artemisia capillaris) with little results. I bought the stuff in consentrated form and put it in to capsuls, maybe the leaf form works better after you boil it
Me:
This is a follow-up to the original post by piraterocker on Yin Zhi Huang tea, which has been shown to activate the UGT1A1 enzyme which leads to reduction of bilirubin in the blood serum. It appears to work the same way as phenobarbitol but without the bad side-effects. Here is the article:
http://www.pubmedcentral.gov/articlerender.fcgi?artid=300765
The article is a bit thick, but it basically says the tea contains four different plants: Artemisia capillaris, Gardenia jasminoides Ellis, Rheum officinale Baill, and Scutellaria baicalensis Georgi. The active ingredient in bilirubin clearance is called Yin Chin, and the active chemical in it is called 6,7-Dimethylesculetin.
This could be a big help to us all. Has anyone tried this tea or herb? I heard from someone that Yin Zhi Huang tea is hard or impossible to find
I'm doing more research. The main ingredient seems to be more commonly referred to as "Yin Chen". It's latin name appears to be Herba Artemisiae Scopariae.
I'm also seeing it as Yin Chen Hao, with the name Artemisia Capillaris. From this site: http://www.kalyx.com/store/proddetail.cfm/ItemID/286363.0/CategoryID/13000.0/SubCatID/2850.0/file.htm
Yin Chen Hao has been used in Chinese herbal medicine for over 2,000 years. Artemisia Capillaris herb is traditionally used as a tea, decoction and smoke. It is a sedative and healthful tea.
Softly aromatic, cool and lacy, native to northern China, Japan and Taiwan, yin chen hao is hardy in the coldet climes. Bitter and acrid, yin chen hao works on the liver, stomach, spleen and gall bladder to clear jaundice, fever and treat hepatitis. It is considered a premier hepatoprotective herb in traditional Chinese medicine.
Artemisia Capillaris, Capillary Wormwood, increases secretion of bile into the gastrointestinal tract thus aiding the liver in draining its waste products. This herb in combination with Gardenia Jasminoidis has been shown to increase the rate of liver cell regeneration.
Yin Chen Hao is contraindicated for pregnant women.
This site sells it in several non-mixed forms, which is probably best for discerning its effect. Pill form: http://www.kalyx.com/store/proddetail.cfm/ItemID/286348.0/CategoryID/1000.0/SubCatID/10.0/file.htm
Other pure sources:
http://maxnature.stores.yahoo.net/yinchorwo130.html
Other sites selling versions of Yin Chen mixed with other things:
http://www.fitnessinsanity.com/cleansesmart.html
http://www.global-nutrition-inc.com/rl-020.html
http://maxnature.stores.yahoo.net/yinchwulisan.html